Mathematical and computer tools are developed at IFR96 for modelling the functions under study

Methods and models for functional neuroimaging (U825)

  • Perfusion imaging and imaging of activation by magnetic resonance and positron emission tomography: microcirculatory basis; analysis and quantification of images; comparison of modes.
  • Localization of brain electrical sources; functional connectivity by analysis of EEG signal synchrony; fusion of EEG/functional tomography and anatomy images.
  • Functional neuroimaging and psychophysiology of brain activation: psychophysical basis and perceptive representations; experimental validation of activation data; connectivity modelling.

Modelling visual processing (CerCo)

Modelling of neuronal processes involved in the identification and categorizing of objects. The following paths are being explored more specifically:
  • Time coding. Study of different forms of time coding where the order in which neurones discharge plays an essential role.
  • Functional architecture. Study of feedforward, feedback and horizontal connections necessary for certain processing. 
  • Learning. Analysis of learning rules that can operate in pulsed neural networks and study of representations used in the ventral pathway. 
  • Development of applications – economic value. Thanks to the SpikeNet Technology start-up company (, the processing algorithms developed are used in commercial image processing and analysis systems.

Cerebral haemodynamics (U825)

This work focuses on modelling functional brain images obtained by PET and fMRI.
  • 3D digitizing of microvascular networks of the human cerebral cortex in optical and confocal laser microscopy.
  • Development of software for the morphometric characterization of these networks. 
  • Study of the effects of 3D capillary density on the haemodynamic response to arteriolar vasodilatation.