Mathematical and computer tools are developed at IFR96 for modelling the functions under study

Methods and models for functional neuroimaging (U825)

  • Perfusion imaging and imaging of activation by magnetic resonance and positron emission tomography: microcirculatory basis; analysis and quantification of images; comparison of modes.
  • Localization of brain electrical sources; functional connectivity by analysis of EEG signal synchrony; fusion of EEG/functional tomography and anatomy images.
  • Functional neuroimaging and psychophysiology of brain activation: psychophysical basis and perceptive representations; experimental validation of activation data; connectivity modelling.


Modelling visual processing (CerCo)

Modelling of neuronal processes involved in the identification and categorizing of objects. The following paths are being explored more specifically:
  • Time coding. Study of different forms of time coding where the order in which neurones discharge plays an essential role.
  • Functional architecture. Study of feedforward, feedback and horizontal connections necessary for certain processing. 
  • Learning. Analysis of learning rules that can operate in pulsed neural networks and study of representations used in the ventral pathway. 
  • Development of applications – economic value. Thanks to the SpikeNet Technology start-up company (www.spikenet-technology.com), the processing algorithms developed are used in commercial image processing and analysis systems.


Cerebral haemodynamics (U825)

This work focuses on modelling functional brain images obtained by PET and fMRI.
  • 3D digitizing of microvascular networks of the human cerebral cortex in optical and confocal laser microscopy.
  • Development of software for the morphometric characterization of these networks. 
  • Study of the effects of 3D capillary density on the haemodynamic response to arteriolar vasodilatation.